NCBI Description
This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients. [provided by RefSeq, Oct 2016]
Uniprot Description
SASH1: May have a role in a signaling pathway. Could act as a tumor suppressor.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 6q24.3-q25.1
Cellular Component: protein complex
Molecular Function: mitogen-activated protein kinase kinase kinase binding; protein C-terminus binding; protein complex scaffold activity; protein kinase binding
Biological Process: positive regulation of angiogenesis; positive regulation of endothelial cell migration; positive regulation of JUN kinase activity; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; positive regulation of p38MAPK cascade; protein polyubiquitination; regulation of protein K63-linked ubiquitination
Product Notes
The Fish SASH1 sash1 (Catalog #
AAA9901357) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9901357 ELISA Kit recognizes Fish SASH1.
It is sometimes possible for the material contained within the vial of
"SAM and SH3 Domain-Containing Protein 1 (SASH1), ELISA Kit" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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