Polyphosphoinositide phosphatase (FIG4) Recombinant Protein | FIG4 recombinant protein

Recombinant Human Polyphosphoinositide phosphatase (FIG4) , partial

• Gene Names: FIG4; YVS; BTOP; SAC3; ALS11; CMT4J; KIAA0274; dJ249I4.1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Polyphosphoinositide phosphatase (FIG4); Recombinant Human Polyphosphoinositide phosphatase (FIG4); partial; FIG4 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 907

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for FIG4 recombinant protein

This protein belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.

NCBI and Uniprot Product Information

• NCBI GI #: 7662034
• NCBI GeneID: 9896
• NCBI Accession #: NP_055660.1
• NCBI GenBank Nucleotide #: NM_014845.5
• UniProt Accession #: Q92562; Q53H49; Q5TCS6
• Molecular Weight: 103,635 Da
• NCBI Official Full Name: polyphosphoinositide phosphatase
• NCBI Official Synonym Full Names: FIG4 phosphoinositide 5-phosphatase
• NCBI Official Symbol: FIG4
• NCBI Official Synonym Symbols: YVS; BTOP; SAC3; ALS11; CMT4J; KIAA0274; dJ249I4.1
• NCBI Protein Information: polyphosphoinositide phosphatase
• UniProt Protein Name: Polyphosphoinositide phosphatase
• Protein Family: Polyphosphoinositide phosphatase
• UniProt Gene Name: FIG4
• UniProt Synonym Gene Names: KIAA0274; SAC3

NCBI Description

The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]

Uniprot Description

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.