Fibroblast growth factor receptor 2 (FGFR2) Recombinant Protein | FGFR2 recombinant protein

Recombinant Chicken Fibroblast growth factor receptor 2 (FGFR2)

• Gene Names: FGFR2; BEK; cek3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Fibroblast growth factor receptor 2 (FGFR2); Recombinant Chicken Fibroblast growth factor receptor 2 (FGFR2); Fibroblast growth factor receptor 2; FGFR-2; EC=2.7.10.1; Tyrosine kinase receptor CEK3; FGFR2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 24-379
• Sequence: RPSFNLV VEDATLEPEE PPTKYQISQP DVHSALPGEP LELRCQLKDA VMISWTKDGV PLGPDNRTVI IGEYLQIKDA SPRDSGLYAC TAIRTLDSDT LYFIVNVTDA LSSGDDEDDN DGSEDFVNDS NQMRAPYWTH TDKMEKRLHA VPAANTVKFR CPAMGNPTPT MRWLKNGKEF KQEHRIGGYK VRNQHWSLIM ESVVPSDKGN YTCIVENQYG SINHTYHLDV VERSPHRPIL QAGLPANASA VVGGDVEFVC KVYSDAQPHI QWIKHVERNG SKYGPDGLPY LQVLKAAGVN TTDKEIEVLY IRNVTFEDAG EYTCLAGNSI GISFHTAWLT VLPAPEKEKE FPTSPDYLE
• Sequence Length: 356

• Species: Gallus gallus (Chicken)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 45384352
• NCBI GeneID: 396259
• NCBI Accession #: NP_990650.1
• NCBI GenBank Nucleotide #: NM_205319.2
• UniProt Accession #: P18461
• Molecular Weight: 92,299 Da
• NCBI Official Full Name: fibroblast growth factor receptor 2
• NCBI Official Synonym Full Names: fibroblast growth factor receptor 2
• NCBI Official Symbol: FGFR2
• NCBI Official Synonym Symbols: BEK; cek3
• NCBI Protein Information: fibroblast growth factor receptor 2; FGFR-2; receptor tyrosine kinase; tyrosine kinase receptor CEK3; chicken tyrosine kinase (cek3)
• UniProt Protein Name: Fibroblast growth factor receptor 2
• Protein Family: Fibroblast growth factor receptor
• UniProt Gene Name: FGFR2
• UniProt Synonym Gene Names: CEK3; FGFR-2
• UniProt Entry Name: FGFR2_CHICK

Uniprot Description

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 ().