Fibroblast growth factor receptor 2 Recombinant Protein | FGFR2 recombinant protein
Fibroblast growth factor receptor 2
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 ().
Research Articles on FGFR2
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Product Notes
The FGFR2 fgfr2 (Catalog #AAA7042743) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 24-823aa; full length protein. The amino acid sequence is listed below: RPSFNLVVED ATLEPEEPPT KYQISQPDVH SALPGEPLEL RCQLKDAVMI SWTKDGVPLG PDNRTVIIGE YLQIKDASPR DSGLYACTAI RTLDSDTLYF IVNVTDALSS GDDEDDNDGS EDFVNDSNQM RAPYWTHTDK MEKRLHAVPA ANTVKFRCPA MGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV VPSDKGNYTC IVENQYGSIN HTYHLDVVER SPHRPILQAG LPANASAVVG GDVEFVCKVY SDAQPHIQWI KHVERNGSKY GPDGLPYLQV LKAAGVNTTD KEIEVLYIRN VTFEDAGEYT CLAGNSIGIS FHTAWLTVLP APEKEKEFPT SPDYLEIAIY CIGVFLIACM VLTVILCRMK NTTKKPDFSS QPAVHKLTKR IPLRRQVTVS ADSSSSMNSN TPLVRITTRL SSTADAPMLA GVSEYELPED PKWEFPRDKL TLGKPLGEGC FGQVVMAEAV GIDKDRPKEA VTVAVKMLKD DATEKDLSDL VSEMEMMKMI GKHKNIINLL GACTQDGPLY VIVEYASKGN LREYLRARRP PGMEYSFDIN RVPEEQMTFK DLVSCTYQLA RGMEYLASQK CIHRDLAARN VLVTENNVMK IADFGLARDI NNIDYYKKTT NGRLPVKWMA PEALFDRVYT HQSDVWSFGV LMWEIFTLGG SPYPGIPVEE LFKLLKEGHR MDKPANCTNE LYMMMRDCWQ AVPSQRPTFK QLVEDLDRIL TLTTNEEYLD LSGPLEQYSP SYPDTRSSCS SGDDSVFSPD PMPYEPCLPK YQHMNGSVKT. It is sometimes possible for the material contained within the vial of "Fibroblast growth factor receptor 2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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