Rabbit anti-Human KAT5 Polyclonal Antibody | anti-KAT5 antibody

KAT5 (Histone Acetyltransferase KAT5, 60kD Tat-interactive Protein, Tip60, Histone Acetyltransferase HTATIP, HIV-1 Tat Interactive Protein, Lysine Acetyltransferase 5, cPLA(2)-interacting Protein, HTATIP, TIP60) (HRP)

Cat. Num. AAA6383436

• Gene Names: KAT5; TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KAT5; Polyclonal Antibody; KAT5 (Histone Acetyltransferase KAT5; 60kD Tat-interactive Protein; Tip60; Histone Acetyltransferase HTATIP; HIV-1 Tat Interactive Protein; Lysine Acetyltransferase 5; cPLA(2)-interacting Protein; HTATIP; TIP60) (HRP); anti-KAT5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human KAT5.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-KAT5 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full-length human KAT5, aa1-513 (NP_006379.2).
• Immunogen Sequence: MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HTATIP rabbit polyclonal antibody. Western Blot analysis of HTATIP expression in A-431.)

Western Blot (WB)

(Western Blot analysis of KAT5 expression in transfected 293T cell line by KAT5 polyclonal antibody. Lane 1: HTATIP transfected lysate (58.6kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-KAT5 antibody

TIP60 is a transcription factor, originally isolated as an HIV-1 TAT-interactive protein, known to interact with the viral TAT protein that leads to HTATIP polyubiquitination and targets it for degradation. It belongs to the MYST family of histone acetyl transferases (HATs). TIP60 is a catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. A co-regulator of transcription factors, TIP60 either promotes or suppresses tumorigenesis. TIP60 is an enzyme that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Product Categories/Family for anti-KAT5 antibody

Antibodies; Enzymes; Acetyltransferase

NCBI and Uniprot Product Information

• NCBI GI #: 36287049
• NCBI GeneID: 10524
• NCBI Accession #: NP_006379.2
• NCBI GenBank Nucleotide #: NM_006388.2
• UniProt Accession #: Q92993; O95624; Q13430; Q17RW5; Q561W3; Q6GSE8; Q9BWK7; B4E3C7; C9JL99
• Molecular Weight: 56,292 Da
• NCBI Official Full Name: histone acetyltransferase KAT5 isoform 2
• NCBI Official Synonym Full Names: lysine acetyltransferase 5
• NCBI Official Symbol: KAT5
• NCBI Official Synonym Symbols: TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1
• NCBI Protein Information: histone acetyltransferase KAT5
• UniProt Protein Name: Histone acetyltransferase KAT5
• Protein Family: 3-ketoacyl-CoA thiolase
• UniProt Gene Name: KAT5
• UniProt Synonym Gene Names: HTATIP; TIP60; Tip60
• UniProt Entry Name: KAT5_HUMAN

NCBI Description

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.

Protein type: Nucleolus; Nuclear receptor co-regulator; EC 2.3.1.48; Acetyltransferase

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleoplasm; transcription factor complex; NuA4 histone acetyltransferase complex; perinuclear region of cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: protein binding; histone acetyltransferase activity; androgen receptor binding; metal ion binding; transcription coactivator activity; protein complex binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; viral reproduction; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of interleukin-2 production; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; regulation of growth; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; response to ionizing radiation; histone acetylation; negative regulation of transcription, DNA-dependent