Fibroblast growth factor 1 (FGF1) Recombinant Protein | FGF1 recombinant protein

Recombinant Dog Fibroblast growth factor 1 (FGF1)

Cat. Num. AAA958899

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Fibroblast growth factor 1 (FGF1); Recombinant Dog Fibroblast growth factor 1 (FGF1); Recombinant Fibroblast growth factor 1 (FGF1); Fibroblast growth factor 1; FGF-1; Acidic fibroblast growth factor; aFGF Endothelial cell growth factor; ECGF Heparin-binding growth factor 1; HBGF-1; FGF1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-15aa; Full length protein
• Sequence: NYMKPKLLYX SNGGH
• Sequence Length: 15

• Species: Canis familiaris (Dog) (Canis lupus familiaris)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Related Product Information for FGF1 recombinant protein

This protein is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.

NCBI and Uniprot Product Information

• NCBI GI #: 122735
• UniProt Accession #: P18651
• Molecular Weight: 1,733 Da
• NCBI Official Full Name: Fibroblast growth factor 1
• UniProt Protein Name: Fibroblast growth factor 1
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF1
• UniProt Synonym Gene Names: FGF-1; aFGF; ECGF; HBGF-1
• UniProt Entry Name: FGF1_CANFA

Uniprot Description

Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro

By similarity.

Subunit structure: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu2+-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13

By similarity.

Subcellular location: Secreted

By similarity. Cytoplasm

By similarity. Cytoplasm › cell cortex

By similarity. Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13. Secreted in a complex with SYT1

By similarity.

Sequence similarities: Belongs to the heparin-binding growth factors family.