Mouse FYVE, RhoGEF and PH domain containing 1 ELISA Kit | FGD1 elisa kit
Mouse FYVE, RhoGEF and PH domain-containing protein 1, FGD1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as molecular switches in signaling. This protein specifically binds cell division cycle 42, a Rho (Ras homology) GTPase. Investigations in mouse suggest that this protein is important for skeletal mineralization and for regulating the actin cytoskeleton. In humans, mutations in this gene are associated with faciogenital dysplasia, also known as Aarskog-Scott syndrome. [provided by RefSeq, Mar 2014]
Uniprot Description
FGD1: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Interacts with DBNL/ABP1 and CTTN. May interact with CCPG1. Binds CDC42. Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.
Protein type: GEFs; GEFs, misc.
Cellular Component: ruffle; Golgi apparatus; cytoskeleton; cell projection; lamellipodium; cytoplasm
Molecular Function: small GTPase binding; protein binding; Rho guanyl-nucleotide exchange factor activity; metal ion binding; guanyl-nucleotide exchange factor activity
Biological Process: regulation of cell shape; filopodium formation; regulation of Rho protein signal transduction; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity
Research Articles on FGD1
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Product Notes
The Mouse FGD1 fgd1 (Catalog #AAA9334076) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334076 ELISA Kit recognizes Mouse FGD1. It is sometimes possible for the material contained within the vial of "FYVE, RhoGEF and PH domain containing 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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