Human FYVE, RhoGEF and PH domain containing 1 ELISA Kit | FGD1 elisa kit
Human FYVE, RhoGEF and PH domain-containing protein 1, FGD1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.[provided by RefSeq, Mar 2011]
Uniprot Description
FGD1: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Interacts with DBNL/ABP1 and CTTN. May interact with CCPG1. Binds CDC42. Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.
Protein type: GEFs, misc.; GEFs
Chromosomal Location of Human Ortholog: Xp11.21
Cellular Component: ruffle; Golgi apparatus; cytoskeleton; lamellipodium; cytoplasm; cytosol
Molecular Function: small GTPase binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; metal ion binding
Biological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; organ morphogenesis; filopodium formation; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; multicellular organismal development; small GTPase mediated signal transduction; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis; signal transduction; positive regulation of GTPase activity
Disease: Aarskog-scott Syndrome
Research Articles on FGD1
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Product Notes
The Human FGD1 fgd1 (Catalog #AAA9341745) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9341745 ELISA Kit recognizes Human FGD1. It is sometimes possible for the material contained within the vial of "FYVE, RhoGEF and PH domain containing 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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