Uniprot Description
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Product Notes
The ffh ffh (Catalog #
AAA1053042) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-448, Full length protein. The amino acid sequence is listed below: MFQALSDGFK NALNKIRFQD DEKALDRALD ELKKTLLKND VHHKVARELL KKVESQTKLN GIGKQQFLDA LEKSLLEILS AKGSSGFTFA QTPPTVVLMA GLQGSGKTTT TAKLAHYLKT KNKKVLLCAC DLQRLAAVEQ LKVLGEQVGV EVFYEENKSV KEIASNALKR AKEAQFDVLL VDSAGRLAID KELMQELKEV KEILNPHEVL YVADALSGQD GVKSANTFNE EIGVSGVVLS KFDSDSKGGI ALGITYQLGL PLRFIGSGEK IPDLDVFVPE RIVGRLMGAG DIVSLAEKTA SVLNPNEAKD LSKKLKKGQF TFNDFLNQIE KVKKLGSMSS LISMIPGLGN MASALKDTDL ESSLEVKKIK AMVNSMTKKE QENPEILNGS RRKRIALGSG LEVSEINRII KRFDQASKMA KRLTNKKGIS DLMNLMSQAK NQTPPKMR.
It is sometimes possible for the material contained within the vial of
"Signal recognition particle protein (ffh), Recombinant Protein" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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