Western Blot (WB)
(COLO 320 cells were subjected to SDS PAGE followed by western blot with MBS769496 (FZD5 Antibody) at dilution of 1:600)
Rabbit anti-Human FZD5 Polyclonal Antibody | anti-FZD5 antibody
FZD5 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(COLO 320 cells were subjected to SDS PAGE followed by western blot with MBS769496 (FZD5 Antibody) at dilution of 1:600)
Western Blot (WB)
(COLO 320 cells were subjected to SDS PAGE followed by western blot with MBS769496 (FZD5 Antibody) at dilution of 1:600)
NCBI and Uniprot Product Information
NCBI Description
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]
Uniprot Description
FZD5: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family.
Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, Fz/Smo family; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2q33.3
Cellular Component: cell surface; early endosome membrane; Golgi membrane; integral to membrane; perinuclear region of cytoplasm; plasma membrane; tight junction
Molecular Function: beta-amyloid binding; G-protein coupled receptor activity; protein binding; protein kinase binding; ubiquitin protein ligase binding; Wnt receptor activity; Wnt-protein binding
Biological Process: angiogenesis; cell maturation; determination of anterior/posterior axis, embryo; embryonic axis specification; embryonic camera-type eye morphogenesis; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; neuron differentiation; positive regulation of interferon-gamma production; positive regulation of JNK activity; positive regulation of T cell cytokine production; positive regulation of transcription from RNA polymerase II promoter; post-embryonic camera-type eye development; Spemann organizer formation; synaptogenesis; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on FZD5
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Product Notes
The FZD5 fzd5 (Catalog #AAA769496) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FZD5 Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FZD5 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the FZD5 fzd5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FZD5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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