Fetuin B Recombinant Protein | FETUB recombinant protein

Fetuin B Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8120990

• Gene Names: FETUB; 16G2; Gugu; IRL685
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Fetuin B; Fetuin B Protein; Human; Recombinant (His Tag); Human Fetuin-B/FETUB Protein (His Tag); 16G2 Protein; Gugu Protein; IRL685 Protein; fetuin B; FETUB recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Pro382

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Met 19
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human FETUB (NP_055190.2)(Met 1-Pro 382) was expressed, with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for FETUB recombinant protein

Background: Fetuin-B, also known as Fetuin-like protein IRL685 and FETUB, is a secreted protein which belongs to thefetuin family. Fetuin-B/FETUB contains twocystatin domains. Fetuin-B is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption. Fetuin-A has been identified as a major protein during fetal life and is also involved in important functions such as protease inhibitory activities and development-associated regulation of calcium metabolism and osteogenesis. Fetuin-A is a key partner in the recovery phase of an acute inflammatory response. Fetuin-B/FETUB is found at least in human and rodents. It is unambiguously a paralogue of Fetuin-A. Fetuin-A and Fetuin-B exhibit significant differences at the amino acid sequence level, notably including variations with respect to the archetypal fetuin-specific signature.

References

Olivier E., et al., 2000, Biochem. J. 350:589-97 Liu T., et al., 2005, J. Proteome Res. 4:2070-80. Hsu SJ, et al., 2005, Genome. 47 (5): 931-46. Liu T, et al., 2006, J. Proteome Res.4 (6): 2070-80.

NCBI and Uniprot Product Information

• NCBI GI #: 58331240
• NCBI GeneID: 26998
• NCBI Accession #: NP_055190.2
• NCBI GenBank Nucleotide #: NM_014375.2
• UniProt Accession #: Q9UGM5; Q1RMZ0; Q5J876; Q6DK58; Q6GRB6; Q9Y6Z0; B2RCW6; E9PG06
• Molecular Weight: 37,823 Da
• NCBI Official Full Name: fetuin-B
• NCBI Official Synonym Full Names: fetuin B
• NCBI Official Symbol: FETUB
• NCBI Official Synonym Symbols: 16G2; Gugu; IRL685
• NCBI Protein Information: fetuin-B; fetuin-like protein IRL685
• UniProt Protein Name: Fetuin-B
• Protein Family: Fetuin
• UniProt Gene Name: FETUB
• UniProt Entry Name: FETUB_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]

Uniprot Description

FETUB: is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular space

Molecular Function: metalloendopeptidase inhibitor activity; cysteine protease inhibitor activity

Biological Process: binding of sperm to zona pellucida; single fertilization