Flap endonuclease 1 (fen) Recombinant Protein | fen recombinant protein
Recombinant Korarchaeum cryptofilum Flap endonuclease 1 (fen)
NCBI and Uniprot Product Information
Uniprot Description
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA ().
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Product Notes
The fen fen (Catalog #AAA1025889) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-342, Full length protein. The amino acid sequence is listed below: MGVKIGELIE DKVELELSDI AGKKIALDAF NAMYQFLAKV RQPDGTPLMT SKGEITSVHS GIFYRTANFL KEGIIPIYVF DGEKPSFKSR AIEERVRARE EAELKWKEAL EIGDLEEARK YAQAALNITG DIVEDCKTIL KLMGVPIVQA PSEGEAQAAH MAMKGDVWAT ASQDYDSLLF GAPRLIRNLT ITGKRKLPGK EVYVDINPEL IELESVLKRN GISREQLIMI GILVGTDYNL GGVKGIGVKR ALELVKKYKR PEDLFSKVPW EFDVDPISIY EFFLNPPTTD DYDTSLKRPM SDELLKFMVE EHEFSEERVK KVINEIEESY RMLSGGGLES WF. It is sometimes possible for the material contained within the vial of "Flap endonuclease 1 (fen), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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