CD115, Fc Chimera Active Protein
CD115, Recombinant, Human, Fc Chimera (BSA Free) (c-fms, Fms, CSF-1R, M-CSFR)
Reactivity
Feline
Purity
Affinity Purified97%, as determined by SDS-PAGE and visualized by silver stain.
Synonyms
CD115; Fc Chimera; Recombinant; Human; Fc Chimera (BSA Free) (c-fms; Fms; CSF-1R; M-CSFR); Fc Chimera active protein
Reactivity
Feline
Purity/Purification
Affinity Purified
97%, as determined by SDS-PAGE and visualized by silver stain.
97%, as determined by SDS-PAGE and visualized by silver stain.
Form/Format
Supplied as a lyophilized powder from a 0.2um sterile-filtered solution in PBS. It is recommended that sterile PBS containing at least 0.1% HSA or BSA be added to the vial to prepare a stock solution of no less than 50mg/ml. Also available with BSA. See C
Activity
Measured by its ability to inhibit the M-CSF induced proliferation of M-NFS-60 cells (Halenbeck, R. et al., 1989, Biotechnology 7:710). The ED50 for this effect is typically 0.004-0.012mg/ml in the presence of 1ng/ml of rhM-CSF.
Endotoxin Level
0.1ng/mg of the cytokine as determined by the LAL method.
Preparation and Storage
Lyophilized samples are stable for greater than six months at -20 degree C to -70 degree C. Upon reconstitution, this cytokine can be stored under sterile conditions at 2-4 degree C for one month
or at -20 to -70 degree C for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
or at -20 to -70 degree C for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Related Product Information for CD115, Fc Chimera active protein
CD115 is also known as c-fms, marcophage colony stimulating factor receptor, or CSF-1R. It exists in immature (gp130 c-fms) and mature (gp150 c-fms) forms. CSF-1R exhibits an intrinsic tyrosine-specific protein kinase activity. It is expressed on the cells of the mononuclear phagocyte lineage. CSF-1R is an integral transmembrane glycoprotein consisting of a 512 amino acid extracellular domain that includes the CSF-1 binding site, a single 25 amino acid membrane-spanning segment, and a 435 amino acid cytoplasmic portion that includes the tyrosine kinase domain.
Product Categories/Family for CD115, Fc Chimera active protein
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Product Notes
The CD115, Fc Chimera (Catalog #AAA637832) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The CD115, Recombinant, Human, Fc Chimera (BSA Free) (c-fms, Fms, CSF-1R, M-CSFR) reacts with Feline and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "CD115, Fc Chimera, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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