Fc receptor-like protein 3 (FCRL3) Recombinant Protein | FCRL3 recombinant protein

Recombinant Human Fc receptor-like protein 3 (FCRL3), partial

Cat. Num. AAA1288578

• Gene Names: FCRL3; FCRH3; IFGP3; IRTA3; SPAP2; CD307c
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Fc receptor-like protein 3 (FCRL3); Recombinant Human Fc receptor-like protein 3 (FCRL3); partial; FCRL3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 18-573aa; Extracellular Domain
• Sequence: GVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYHDEKLLKIKHDKIQITEPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNVILRCQGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSKYHCTAYRKFYILDIEVTSKPLNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGLGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTGGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRYYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYRFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLT

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for FCRL3 recombinant protein

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.

NCBI and Uniprot Product Information

• NCBI GI #: 998614219
• NCBI GeneID: 115352
• NCBI Accession #: NP_001307262.1
• NCBI GenBank Nucleotide #: NM_001320333.1
• UniProt Accession #: Q96P31; Q5VXZ8; Q8N6S2; Q96LA4; Q96P27; Q96P28; Q96P29; Q96P30; A0N0M4; A8MTH7; D3DVD2
• Molecular Weight: 77,921 Da
• NCBI Official Full Name: Fc receptor-like protein 3 isoform 3
• NCBI Official Synonym Full Names: Fc receptor like 3
• NCBI Official Symbol: FCRL3
• NCBI Official Synonym Symbols: FCRH3; IFGP3; IRTA3; SPAP2; CD307c
• NCBI Protein Information: Fc receptor-like protein 3
• UniProt Protein Name: Fc receptor-like protein 3
• Protein Family: Fc receptor-like protein
• UniProt Gene Name: FCRL3
• UniProt Synonym Gene Names: FcR-like protein 3Curated; FcRL3Curated; FcRH3Curated; hIFGP3

NCBI Description

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Description

Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).