Rabbit anti-Human FCRL3 Polyclonal Antibody | anti-FCRL3 antibody

FCRL3, CT (FCRL3, FCRH3, IFGP3, IRTA3, SPAP2, Fc receptor-like protein 3, Fc receptor homolog 3, IFGP family protein 3, Immune receptor translocation-associated protein 3, SH2 domain-containing phosphatase anchor protein 2, CD307c) (AP)

Cat. Num. AAA6298725

• Gene Names: FCRL3; FCRH3; IFGP3; IRTA3; SPAP2; CD307c
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FCRL3; Polyclonal Antibody; CT (FCRL3; FCRH3; IFGP3; IRTA3; SPAP2; Fc receptor-like protein 3; Fc receptor homolog 3; IFGP family protein 3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD307c) (AP); CD307c; anti-FCRL3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-FCRL3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: FCRL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 694-720 amino acids from the C-terminal region of human FCRL3.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(FCRL3 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the FCRL3 antibody detected the FCRL3 protein (arrow).)

Related Product Information for anti-FCRL3 antibody

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.

Product Categories/Family for anti-FCRL3 antibody

Antibodies; CD Markers

References

Wu, H., et al. Hum. Immunol. (2010). In press: Swainson, L.A., et al. J. Immunol. 184(7):3639-3647(2010). Davila, S., et al. Genes Immun. 11(3):232-238(2010). Zheng, R., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26(6):681-685(2009). Gibson, A.W., et al. Arthritis Rheum. 60(11):3510-3512(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 21314764
• NCBI GeneID: 115352
• NCBI Accession #: NP_443171.2
• NCBI GenBank Nucleotide #: NM_052939.3
• UniProt Accession #: Q96P31; Q5VXZ8; Q8N6S2; Q96LA4; Q96P27; Q96P28; Q96P29; Q96P30; A0N0M4; A8MTH7; D3DVD2
• Molecular Weight: 77,921 Da
• NCBI Official Full Name: Fc receptor-like protein 3
• NCBI Official Synonym Full Names: Fc receptor-like 3
• NCBI Official Symbol: FCRL3
• NCBI Official Synonym Symbols: FCRH3; IFGP3; IRTA3; SPAP2; CD307c
• NCBI Protein Information: Fc receptor-like protein 3
• UniProt Protein Name: Fc receptor-like protein 3
• Protein Family: Fc receptor-like protein
• UniProt Gene Name: FCRL3
• UniProt Synonym Gene Names: FCRH3; IFGP3; IRTA3; SPAP2; FcR-like protein 3; FcRL3; FcRH3; hIFGP3
• UniProt Entry Name: FCRL3_HUMAN

NCBI Description

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

Uniprot Description

FCRL3: Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: integral to membrane; plasma membrane