CD16b/FCGR3B recombinant protein

Recombinant Human CD16b/FCGR3B (NA2) Protein (C-His)

Cat. Num. AAA2557208

• Gene Names: FCGR3B; CD16; FCG3; CD16A; CD16b; FCGR3; FCGR3A; FCR-10; FCRIII; FCRIIIb
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: CD16b/FCGR3B; Recombinant Human CD16b/FCGR3B (NA2) Protein (C-His); Low affinity immunoglobulin gamma Fc region receptor III-B; Fc-gamma RIII-beta; FcR-10; IgG Fc receptor III-1; FCG3; FCGR3; CD16b and FCGR3B; Fc gamma RIIIB; CD16b/FCGR3B recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Gly17-Gln208
• Sequence Length: 233

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for CD16b/FCGR3B recombinant protein

Protein Construction: Recombinant Human FCGR3B is produced by our mammalian expression system and the target gene encoding Gly17-Gln208 is expressed with a 6His tag at the C-terminus.

Background: Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of inflammation and their activation. FCGR3B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

NCBI and Uniprot Product Information

• NCBI GI #: 7994572
• NCBI GeneID: 2215
• UniProt Accession #: O75015
• Molecular Weight: Molecular Mass: 22.7kDa; Actual Protein Molecular Mass: 35-65kDa
• NCBI Official Full Name: Low affinity immunoglobulin gamma Fc region receptor III-B
• NCBI Official Synonym Full Names: Fc fragment of IgG receptor IIIb
• NCBI Official Symbol: FCGR3B
• NCBI Official Synonym Symbols: CD16; FCG3; CD16A; CD16b; FCGR3; FCGR3A; FCR-10; FCRIII; FCRIIIb
• NCBI Protein Information: low affinity immunoglobulin gamma Fc region receptor III-B
• UniProt Protein Name: Low affinity immunoglobulin gamma Fc region receptor III-B
• UniProt Gene Name: FCGR3B
• UniProt Synonym Gene Names: CD16B; FCG3; FCGR3; IGFR3; Fc-gamma RIII; Fc-gamma RIIIb; FcRIII; FcRIIIb

NCBI Description

The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]

Uniprot Description

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.