FBXW7 Blocking Peptide | FBXW7 (HGNC:16712) blocking peptide
FBXW7 Blocking Peptide (N-term)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Uniprot Description
FBXW7: a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins including MYC, cyclin E, NOTCH1-released notch intracellular domain (NICD), JUN, and probably PSEN1. Recognizes and binds to phosphorylated target proteins. Other components of the SCF(FBXW7) complex are sCUL1, RBX1, and SKP1A. Defects in FBXW7 may be a cause of breast cancer. The homolog of Cdc4, one of the yeast genes that regulate sister chromatid cohesion. Down-regulation or disruption of FBXW7 resulted in abnormal sister chromatid cohesion in human cells. Four alternatively spliced isoforms have been described.
Protein type: Ubiquitin conjugating system; Nucleolus; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4q31.3
Cellular Component: cytoplasm; cytosol; nucleoplasm; SCF ubiquitin ligase complex
Molecular Function: cyclin binding; identical protein binding; phosphothreonine binding; protein binding; protein binding, bridging; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: lipid homeostasis; negative regulation of DNA endoreduplication; negative regulation of Notch signaling pathway; positive regulation of epidermal growth factor receptor activity; positive regulation of protein ubiquitination; positive regulation of ubiquitin-protein ligase activity; protein polyubiquitination; protein stabilization; protein ubiquitination; regulation of protein localization; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; sister chromatid cohesion; vasculature development
Research Articles on FBXW7 (HGNC:16712)
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Product Notes
The FBXW7 (HGNC:16712) fbxw7 (Catalog #AAA9229926) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FBXW7, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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