Fatty Acid Binding Protein 4 Recombinant Protein
Fatty Acid Binding Protein 4, Recombinant, Human (FABP4, A-FABP)
Purity
Highly Purified90% (SDS-PAGE); Two-step procedure using size exclusion chromatography before and after refolding.
Synonyms
Fatty Acid Binding Protein 4; Recombinant; Human (FABP4; A-FABP); Fatty Acid Binding Protein 4 recombinant protein
Host
E Coli
Specificity
The amino acid sequence of the recombinant human FABP4 is 100% homologous to the amino acid sequence of the human FABP4.
Purity/Purification
Highly Purified
90% (SDS-PAGE); Two-step procedure using size exclusion chromatography before and after refolding.
90% (SDS-PAGE); Two-step procedure using size exclusion chromatography before and after refolding.
Form/Format
Supplied as a lyophilized powder in 0.05M acetate buffer, pH 4.0.
Application Notes
Western blotting, ELISA
Reconstitution
0.1M Acetate buffer pH4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10 g/ml. In higher concentrations the solubility of this antigen is limited.
Preparation and Storage
Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid freeze-thaw cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
Related Product Information for Fatty Acid Binding Protein 4 recombinant protein
Adipocyte fatty acid binding protein FABP4 is a 15kD member of the intracellular fatty acid binding protein (FABP) family, which is known for the ability to bind fatty acids and related compounds (bile acids or retinoids) in an internal cavity. FABP4 is expressed in a differentiation-dependent fashion in adipocytes and is a critical gene in the regulation of the biological function of these cells. In mice, targeted mutations in FABP4 provide significant protection from hyperinsulinemia and insulin resistance in the context of both dietary and genetic obesity. Adipocytes obtained from FABP4-deficient mice also have reduced efficiency of ipolysis in vitro and in vivo, and these mice exhibited moderately improved systemic dyslipidemia. Recent studies also demonstrated FABP4 expression in macrophages upon differentiation and activation. In these cells, FABP4 modulates inflammatory responses and cholesterol ester accumulation, and total or macrophage-specific FABP4 deficiency confers dramatic protection against atherosclerosis in the apoE-/- mice. These results indicate a central role for FABP4 in the development of major components of the metabolic syndrome through its distinct actions in adipocytes and macrophages.
Recombinant Human Fatty Acid Binding Protein 4 is a monomeric,non-glycosylated, polypeptide chain containing 132 amino acids and having a molecular mass of 14,700 Daltons.
Recombinant Human Fatty Acid Binding Protein 4 is a monomeric,non-glycosylated, polypeptide chain containing 132 amino acids and having a molecular mass of 14,700 Daltons.
Product Categories/Family for Fatty Acid Binding Protein 4 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
14.7kD
NCBI Official Full Name
fatty acid binding protein 4, partial
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Product Notes
The Fatty Acid Binding Protein 4 (Catalog #AAA637604) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. Western blotting, ELISA. Researchers should empirically determine the suitability of the Fatty Acid Binding Protein 4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fatty Acid Binding Protein 4, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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