(Rhesus macaque) Tumor necrosis factor ligand superfamily member 6 (FASLG) Recombinant Protein | FASLG recombinant protein
Recombinant Macaca mulatta (Rhesus macaque) Tumor necrosis factor ligand superfamily member 6 (FASLG)
NCBI and Uniprot Product Information
Uniprot Description
Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects
By similarity.The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition
By similarity.
Subunit structure: Homotrimer
Probable. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1
By similarity.
Subcellular location: Cell membrane; Single-pass type II membrane protein
By similarity. Cytoplasmic vesicle lumen
By similarity. Lysosome lumen
By similarity. Note: Colocalizes with the SPPL2A protease at the cell membrane. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination
By similarity.Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted
By similarity. Note: May be released into the extracellular fluid, probably by cleavage form the cell surface
By similarity.FasL intracellular domain: Nucleus
By similarity. Note: The FasL ICD cytoplasmic form is translocated into the nucleus
By similarity.
Post-translational modification: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells
By similarity.Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization
By similarity.N-glycosylated
By similarity.Monoubiquitinated
By similarity.
Sequence similarities: Belongs to the tumor necrosis factor family.
Research Articles on FASLG
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Product Notes
The FASLG faslg (Catalog #AAA958780) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 102-280. Covers the extracellular domain. The amino acid sequence is listed below: QLFHLQKELA ELRESTSQKH TASSLEKQIG HPSPPPEKKE QRKVAHLTGK PNSRSMPLEW EDTYGIVLLS GVKYKKGGLV INETGLYFVY SKVYFRGQSC TNLPLSHKVY MRNSKYPQDL VMMEGKMMSY CTTGQMWAHS SYLGAVFNLT SADHLYVNVS ELSLVNFEES QTFFGLYKL . It is sometimes possible for the material contained within the vial of "(Rhesus macaque) Tumor necrosis factor ligand superfamily member 6 (FASLG), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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