Mouse family with sequence similarity 20, member C ELISA Kit | FAM20C elisa kit
Mouse Dentin matrix protein 4, FAM20C ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
FAM20C: an atypical serine protein kinase that localizes within the Golgi apparatus and is secreted. Distantly related to the Drosophila Golgi-localized kinase Four-jointed. Phosphorylates secretory proteins including the caseins and members of the small integrin-binding ligand, N-linked glycoprotein (SIBLING) protein family, which modulate biomineralization. Colocalizes with the Golgi resident protein GM130. Preferentially phosphorylates its targets within the S-x-E/pS motif. Requires Mn2+ as an alternative to Mg2+ as the activating cation. Defects in FAM20C are the cause of Raine syndrome (RNS). RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly. Two isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.11.1; Secreted, signal peptide; Protein kinase, Ser/Thr (non-receptor); Secreted
Cellular Component: Golgi apparatus; extracellular space; extracellular region
Molecular Function: transferase activity; protein serine/threonine kinase activity; metal ion binding; calcium ion binding; kinase activity
Biological Process: positive regulation of osteoblast differentiation; biomineral formation; regulation of fibroblast growth factor receptor signaling pathway; positive regulation of bone mineralization; skeletal development; protein amino acid phosphorylation; phosphorylation; regulation of phosphorus metabolic process
Research Articles on FAM20C
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Product Notes
The Mouse FAM20C fam20c (Catalog #AAA9331878) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331878 ELISA Kit recognizes Mouse FAM20C. It is sometimes possible for the material contained within the vial of "family with sequence similarity 20, member C, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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