Protein FADD (Fadd) Recombinant Protein | Fadd recombinant protein

Recombinant Mouse Protein FADD (Fadd)

Cat. Num. AAA1388724

• Gene Names: Fadd; Mort1/FADD
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Protein FADD (Fadd); Recombinant Mouse Protein FADD (Fadd); Fadd recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-205, full length protein
• Sequence: MDPFLVLLHSLSGSLSGNDLMELKFLCRERVSKRKLERVQSGLDLFTVLLEQNDLERGHTGLLRELLASLRRHDLLQRLDDFEAGTATAAPPGEADLQVAFDIVCDNVGRDWKRLARELKVSEAKMDGIEEKYPRSLSERVRESLKVWKNAEKKNASVAGLVKALRTCRLNLVADLVEEAQESVSKSENMSPVLRDSTVSSSETP
• Sequence Length: 205

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Fadd recombinant protein

This protein is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6
Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10
TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

NCBI and Uniprot Product Information

• NCBI GI #: 6753812
• NCBI GeneID: 14082
• NCBI Accession #: NP_034305.1
• NCBI GenBank Nucleotide #: NM_010175.5
• UniProt Accession #: Q61160; Q3TC37; Q61082
• Molecular Weight: 22,960 Da
• NCBI Official Full Name: FAS-associated death domain protein
• NCBI Official Synonym Full Names: Fas (TNFRSF6)-associated via death domain
• NCBI Official Symbol: Fadd
• NCBI Official Synonym Symbols: Mort1/FADD
• NCBI Protein Information: FAS-associated death domain protein
• UniProt Protein Name: FAS-associated death domain protein
• Protein Family: Long-chain-fatty-acid--CoA ligase
• UniProt Gene Name: Fadd
• UniProt Synonym Gene Names: Mort1

Uniprot Description

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling ().