FABP heart, FABP3 Recombinant Protein | FABP3 recombinant protein
FABP heart, FABP3 Protein (Active)
Gene Names
FABP3; MDGI; FABP11; H-FABP; M-FABP; O-FABP
Applications
ELISA, SDS-Page
Synonyms
FABP heart; FABP3; FABP3 Protein (Active); Fatty Acid Binding Protein 3; FABP3 recombinant protein
Host
E Coli
Form/Format
Liquid
Applicable Applications for FABP3 recombinant protein
ELISA (EIA), SDS-PAGE
Storage Buffer
Each vial contains 20 mM Tris-HCL, 140 mM NaCl, 2 mM EDTA (pH8.0) without preservative.
Storage Buffer
Each vial contains 20 mM Tris-HCL, 140 mM NaCl, 2 mM EDTA (pH8.0) without preservative.
Preparation and Storage
Ship at 4 degree C. Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term. Avoid repeated freeze and thaw cycles
Related Product Information for FABP3 recombinant protein
Recombinant full length human FABP protein with molecular weight 15 kDa.
Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is encoded by the FABP3 gene. It is a small cytoplasmic protein (15 kDa) released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, H-FABP is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. H-FABP is a sensitive biomarker for myocardial infarction and can be detected in the blood within one to three hours of the pain. It is also the biomarker for heart injury. In addition to its potential, H-FABP also has prognostic value. Alongside D-dimer, NT-proBNP and peak troponin T, it was the only cardiac biomarker that proved to be a statistically significant predictor of death or Mi at one year.
Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is encoded by the FABP3 gene. It is a small cytoplasmic protein (15 kDa) released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, H-FABP is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. H-FABP is a sensitive biomarker for myocardial infarction and can be detected in the blood within one to three hours of the pain. It is also the biomarker for heart injury. In addition to its potential, H-FABP also has prognostic value. Alongside D-dimer, NT-proBNP and peak troponin T, it was the only cardiac biomarker that proved to be a statistically significant predictor of death or Mi at one year.
References
1. Kleine AH, Glatz JF, Van Nieuwenhoven FA, Van der Vusse GJ (October 1992). "Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man". Mol. Cell. Biochem. 116 (1-2): 155-62. 2. Tanaka T, Hirota Y, Sohmiya K, Nishimura S, Kawamura K (April 1991). "Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction". Clin. Biochem. 24 (2): 195-201. 3. Watanabe K, Wakabayashi H, Veerkamp JH, Ono T, Suzuki T (May 1993). "Immunohistochemical distribution of heart-type fatty acid-binding protein immunoreactivity in normal human tissues and in acute myocardial infarct". J. Pathol. 170 (1): 59-65.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
14,858 Da
NCBI Official Full Name
fatty acid-binding protein, heart
NCBI Official Synonym Full Names
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
NCBI Official Symbol
FABP3
NCBI Official Synonym Symbols
MDGI; FABP11; H-FABP; M-FABP; O-FABP
NCBI Protein Information
fatty acid-binding protein, heart; fatty acid binding protein 11; mammary-derived growth inhibitor; muscle fatty acid-binding protein; Fatty acid-binding protein 3, muscle; heart-type fatty acid-binding protein
UniProt Protein Name
Fatty acid-binding protein, heart
Protein Family
UniProt Gene Name
FABP3
UniProt Synonym Gene Names
FABP11; MDGI; H-FABP; MDGI; M-FABP
UniProt Entry Name
FABPH_HUMAN
NCBI Description
The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
Subcellular location: Cytoplasm.
Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Sequence similarities: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Research Articles on FABP3
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Product Notes
The FABP3 fabp3 (Catalog #AAA355562) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's FABP heart, FABP3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), SDS-PAGE. Researchers should empirically determine the suitability of the FABP3 fabp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FABP heart, FABP3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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