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JAM-A/Junctional Adhesion Molecule A Recombinant Protein | F11R recombinant protein
JAM-A/Junctional Adhesion Molecule A Protein, Mouse, Recombinant (hFc Tag)
Gene Names
F11r; JAM; Jcam; JAM-1; JAM-A; Jcam1; Ly106; ESTM33; AA638916; 9130004G24
Purity
>94% as determined by SDS-PAGE
Synonyms
JAM-A/Junctional Adhesion Molecule A; JAM-A/Junctional Adhesion Molecule A Protein; Mouse; Recombinant (hFc Tag); Mouse JAM-A/F11R Protein (Fc Tag); 9130004G24 Protein; AA638916 Protein; ESTM33 Protein; JAM Protein; JAM-1 Protein; JAM-A Protein; Jcam Protein; Jcam1 Protein; Ly106 Protein; F11 receptor; F11R recombinant protein
Host
HEK293 Cells
Purity/Purification
>94% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Sequence
Met1-Ala242
Species
Mouse
Endotoxin
<1.0EU per ug of the protein as determined by the LAL method
Predicted N Terminal
Lys 27
Tag
C-human IgG1-Fc
Protein Construction
A DNA sequence encoding the mouse F11R (NP_766235.1) extracellular domain (Met 1-Ala 242) was fused with the Fc region of human IgG1 at the C-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
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Related Product Information for F11R recombinant protein
Background: Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.
References
Guglielmi KM, et al. (2007) Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem. 282(24): 17930-40.Yeung D, et al. (2008) Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol. 115(6): 635-42.Ong KL, et al. (2009) Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension. Am J Hypertens. 22(5): 500-5.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
32,424 Da
NCBI Official Full Name
junctional adhesion molecule A
NCBI Official Synonym Full Names
F11 receptor
NCBI Official Symbol
F11r
NCBI Official Synonym Symbols
JAM; Jcam; JAM-1; JAM-A; Jcam1; Ly106; ESTM33; AA638916; 9130004G24
NCBI Protein Information
junctional adhesion molecule A; BV11 antigen; F11 receptor/F11R; junction cell adhesion molecule A; junction cell adhesion molecule1; junctional adhesion molecule 1
UniProt Protein Name
Junctional adhesion molecule A
Protein Family
UniProt Gene Name
F11r
UniProt Synonym Gene Names
Jam1; Jcam; Jcam1; JAM-A; JAM-1
UniProt Entry Name
JAM1_MOUSE
Uniprot Description
JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily.
Protein type: Membrane protein, integral; Cell adhesion
Cellular Component: microtubule cytoskeleton; tight junction; membrane; integral to membrane; plasma membrane; intercellular junction; cytoplasmic vesicle; cell junction
Molecular Function: protein binding; PDZ domain binding
Biological Process: viral reproduction; epithelial cell differentiation; actomyosin structure organization and biogenesis; cell adhesion; positive regulation of blood pressure; intestinal absorption
Research Articles on F11R
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Product Notes
The F11R f11r (Catalog #AAA8122758) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Met1-Ala24 2. It is sometimes possible for the material contained within the vial of "JAM-A/Junctional Adhesion Molecule A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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