ETFB / Electron Transfer Flavoprotein Subunit Beta Recombinant Protein | ETFB recombinant protein

Human ETFB / Electron Transfer Flavoprotein Subunit Beta Recombinant Protein

• Gene Names: ETFB; MADD; FP585
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: ETFB / Electron Transfer Flavoprotein Subunit Beta; Human ETFB / Electron Transfer Flavoprotein Subunit Beta Recombinant Protein; Electron transfer flavoprotein subunit beta; Beta-ETF; FP585; ETFB recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 255

• Applicable Applications for ETFB recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: Electron transfer flavoprotein is a heterodimer composed of ETFA and ETFB (PubMed:8962055). Interacts with ETFRF1 (PubMed:27499296).
• Entry Function: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 4503609
• NCBI GeneID: 2109
• NCBI Accession #: NP_001976.1
• NCBI GenBank Nucleotide #: NP_001976.1
• UniProt Accession #: P38117
• NCBI Official Full Name: electron transfer flavoprotein subunit beta isoform 1
• NCBI Official Synonym Full Names: electron transfer flavoprotein subunit beta
• NCBI Official Symbol: ETFB
• NCBI Official Synonym Symbols: MADD; FP585
• NCBI Protein Information: electron transfer flavoprotein subunit beta
• UniProt Protein Name: Electron transfer flavoprotein subunit beta
• Protein Family: Electron transfer flavoprotein
• UniProt Gene Name: ETFB
• UniProt Synonym Gene Names: Beta-ETF
• UniProt Entry Name: ETFB_HUMAN

NCBI Description

This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ETFB: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Defects in ETFB are the cause of glutaric aciduria type 2B (GA2B). GA2B is an autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Belongs to the ETF beta-subunit/FixA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Mitochondrial

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: intracellular membrane-bound organelle; mitochondrion; mitochondrial matrix

Molecular Function: electron carrier activity

Biological Process: cellular metabolic process

Disease: Multiple Acyl-coa Dehydrogenase Deficiency