Leutenizing hormone Releasing Hormone Native Protein | LHRH native protein
Human Leutenizing hormone Releasing Hormone (Gonadorelin)
Sterile Filtered White lyophilized (freeze-dried) powder.
Introduction: Gonadotropin-releasing hormone 1 (GNRH1), also known as Luteinising-hormone releasing hormone (LHRH), is a peptide hormone responsible for the release of FSH and LH from the anterior pituitary. GNRH1 is synthesized and released by the hypothalamus.At the pituitary, GNRH1 stimulates the synthesis and secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These processes are controlled by the size and frequency of GNRH1 pulses, as well as by feedback from androgens and estrogens. Low requency GNRH1 pulses lead to FSH release, whereas high frequency GNRH1 pulses stimulate LH release.There are differences in GNRH1 secretion between males and females. In males, GNRH1 is secreted in pulses at a constant frequency, but in females the frequency of the pulses varies during the menstrual cycle and there is a large surge of GNRH1 just before ovulation.GNRH1 secretion is pulsatile in all vertebrates, and is necessary for correct reproductive function. Thus, a single hormone, GNRH1, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2012]
Uniprot Description
GNRH1: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Belongs to the GnRH family.
Protein type: Hormone; Cell cycle regulation; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8p21-p11.2
Cellular Component: extracellular space; extracellular region
Molecular Function: hormone activity; luteinizing hormone-releasing factor activity
Biological Process: negative regulation of cell proliferation; ovulation cycle; response to ethanol; cell-cell signaling; regulation of gene expression; multicellular organismal development; female pregnancy; signal transduction; negative regulation of apoptosis; response to corticosteroid stimulus
Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Research Articles on LHRH
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Product Notes
The LHRH gnrh1 (Catalog #AAA142655) is a Native Protein produced from Escherichia Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Pyr-His-Tr p-Ser-Tyr- Gly-Leu-Ar g-Pro-Gly- NH2. It is sometimes possible for the material contained within the vial of "Leutenizing hormone Releasing Hormone, Native Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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