Mouse excision repair cross-complementing rodent repair deficiency, complementation group 4 ELISA Kit | ERCC4 elisa kit
Mouse DNA repair endonuclease XPF, ERCC4 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ERCC4: Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. Defects in ERCC4 are the cause of xeroderma pigmentosum complementation group F (XP-F); also known as xeroderma pigmentosum VI (XP6). XP-F is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Defects in ERCC4 are a cause of XFE progeroid syndrome (XFEPS). This syndrome is illustrated by one patient who presented with dwarfism, cachexia and microcephaly. Belongs to the XPF family.
Protein type: Deoxyribonuclease; DNA repair, damage; EC 3.1.-.-
Cellular Component: nucleotide-excision repair complex; chromosome, telomeric region; transcription factor TFIID complex; nuclear chromosome, telomeric region; nucleus
Molecular Function: protein C-terminus binding; nuclease activity; structure-specific DNA binding; hydrolase activity; single-stranded DNA specific endodeoxyribonuclease activity; protein N-terminus binding; T/G mismatch-specific endonuclease activity; endodeoxyribonuclease activity; phosphoric ester hydrolase activity; protein binding; nucleic acid binding; DNA binding; endonuclease activity; damaged DNA binding; single-stranded DNA binding
Biological Process: nucleotide-excision repair, DNA incision; DNA repair; DNA catabolic process, endonucleolytic; double-strand break repair via homologous recombination; nucleotide-excision repair, DNA incision, 3'-to lesion; negative regulation of telomere maintenance; UV protection; nucleotide-excision repair; resolution of meiotic joint molecules as recombinants; nucleotide-excision repair, DNA incision, 5'-to lesion; response to DNA damage stimulus; DNA metabolic process; telomere maintenance; response to UV
Research Articles on ERCC4
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Product Notes
The Mouse ERCC4 ercc4 (Catalog #AAA9332527) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332527 ELISA Kit recognizes Mouse ERCC4. It is sometimes possible for the material contained within the vial of "excision repair cross-complementing rodent repair deficiency, complementation group 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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