Typical Testing Data/Standard Curve (for reference only)
Human Receptor tyrosine-protein kinase erbB-3 ELISA Kit | ERBB3 elisa kit
Human Receptor tyrosine-protein kinase erbB-3 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described.
Protein type: Oncoprotein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; Membrane protein, integral; TK group; EGFR family
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: apical plasma membrane; basolateral plasma membrane; extracellular space; integral to plasma membrane; intracellular; lateral plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; growth factor binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; protein-tyrosine kinase activity; transmembrane receptor activity
Biological Process: activation of MAPKK activity; axon guidance; cranial nerve development; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; heart development; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of cell adhesion; negative regulation of neuron apoptosis; negative regulation of secretion; negative regulation of signal transduction; nerve growth factor receptor signaling pathway; neuron apoptosis; peripheral nervous system development; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of phosphoinositide 3-kinase cascade; Ras protein signal transduction; regulation of cell proliferation; Schwann cell differentiation; signal transduction; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; wound healing
Disease: Lethal Congenital Contracture Syndrome 2
Research Articles on ERBB3
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Product Notes
The Human ERBB3 erbb3 (Catalog #AAA2886441) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2886441 ELISA Kit recognizes Human ERBB3. It is sometimes possible for the material contained within the vial of "Receptor tyrosine-protein kinase erbB-3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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