Ephrin type-A receptor 8 (Epha8) Recombinant Protein | Epha8 recombinant protein

Recombinant Mouse Ephrin type-A receptor 8 (Epha8), partial

Cat. Num. AAA1229631

• Gene Names: Epha8; Eek; Hek3; AW047546; mKIAA1459
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ephrin type-A receptor 8 (Epha8); Recombinant Mouse Ephrin type-A receptor 8 (Epha8); partial; Epha8 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 27-541
• Sequence: GRGE VNLLDTSTIH GDWGWLTYPA HGWDSINEVD ESFRPIHTYQ VCNVMSPNQN NWLRTNWVPR DGARRVYAEI KFTLRDCNSI PGVLGTCKET FNLHYLESDR DLGASTQESQ FLKIDTIAAD ESFTGADLGV RRLKLNTEVR GVGPLSKRGF YLAFQDIGAC LAILSLRIYY KKCPAMVRNL AAFSEAVTGA DSSSLVEVRG QCVRHSEERD TPKMYCSAEG EWLVPIGKCV CSAGYEERRD ACMACELGFY KSAPGDQLCA RCPPHSHSAT PAAQTCRCDL SYYRAALDPP SAACTRPPSA PVNLISSVNG TSVTLEWAPP LDPGGRSDIT YNAVCRRCPW ALSHCEACGS GTRFVPQQTS LAQASLLVAN LLAHMNYSFW IEAVNGVSNL SPEPRSAAVV NITTNQAAPS QVVVIRQERA GQTSVSLLWQ EPEQPNGIIL EYEIKYYEKD KEMQSYSTLK AVTTRATVSG LKPGTRYVFQ VRARTSAGCG RFSQAMEVET GKPRPRYDTR T
• Sequence Length: 515

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Epha8 recombinant protein

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This protein functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.

NCBI and Uniprot Product Information

• NCBI GI #: 154240697
• NCBI GeneID: 13842
• NCBI Accession #: NP_031965.2
• NCBI GenBank Nucleotide #: NM_007939.2
• UniProt Accession #: O09127; A3KG07
• Molecular Weight: 110,705 Da
• NCBI Official Full Name: ephrin type-A receptor 8
• NCBI Official Synonym Full Names: Eph receptor A8
• NCBI Official Symbol: Epha8
• NCBI Official Synonym Symbols: Eek; Hek3; AW047546; mKIAA1459
• NCBI Protein Information: ephrin type-A receptor 8
• UniProt Protein Name: Ephrin type-A receptor 8
• Protein Family: Ephrin type-A receptor
• UniProt Gene Name: Epha8
• UniProt Synonym Gene Names: Eek

Uniprot Description

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.