Mouse EPH receptor A8 ELISA Kit | EPHA8 elisa kit
Mouse Ephrin type-A receptor 8, EPHA8 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
EphA8: a receptor tyrosine kinase of the Eph family. A receptor for members of the ephrin-A family: ephrin A2, A3 and A5. Plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Contains 1 sterile alpha motif (SAM) domain and 2 fibronectin type III domains.
Protein type: Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; TK group; Eph family
Cellular Component: neuron projection; cell projection; membrane; integral to plasma membrane; integral to membrane; plasma membrane; endosome
Molecular Function: transferase activity; protein binding; protein-tyrosine kinase activity; GPI-linked ephrin receptor activity; transferase activity, transferring phosphorus-containing groups; ephrin receptor activity; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity
Biological Process: substrate-bound cell migration; regulation of cell adhesion; nervous system development; axon guidance; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; multicellular organismal development; positive regulation of phosphoinositide 3-kinase activity; protein amino acid phosphorylation; regulation of cell adhesion mediated by integrin; positive regulation of MAPKKK cascade; ephrin receptor signaling pathway; cell adhesion; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; neurite development; neuron remodeling
Research Articles on EPHA8
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Product Notes
The Mouse EPHA8 epha8 (Catalog #AAA9318417) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318417 ELISA Kit recognizes Mouse EPHA8. It is sometimes possible for the material contained within the vial of "EPH receptor A8, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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