Cholesterol 7alpha (α)-Hydroxylase (CYP7A) ELISA Kit | CYP7A elisa kit
Rat Cholesterol 7alpha (α)-Hydroxylase (CYP7A) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
NR5A2: Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Belongs to the nuclear hormone receptor family. NR5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; phospholipid binding; transcription factor activity
Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; positive regulation of viral genome replication; bile acid metabolic process; positive regulation of transcription, DNA-dependent; endocrine pancreas development; regulation of cell proliferation; embryonic development; cholesterol homeostasis; regulation of transcription, DNA-dependent; homeostatic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling
Research Articles on CYP7A
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Product Notes
The CYP7A nr5a2 (Catalog #AAA9310106) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Cholesterol 7alpha (α)-Hydroxylase (CYP7A), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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