Mouse eukaryotic translation initiation factor 4H ELISA Kit | EIF4H elisa kit
Mouse Eukaryotic translation initiation factor 4H, EIF4H ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Uniprot Description
EIF4H: eukaryotic translation initiation factor 4H stimulates protein translation. May stimulate the activities of EIF4A, EIF4B and EIF4F during the steps involving mRNA binding and utilization in the initiation of protein biosynthesis. Binds mRNA. Two alternatively spliced isoforms have been described. The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney.
Protein type: RNA-binding; Translation; Translation initiation
Cellular Component: membrane; cytoplasm
Molecular Function: nucleic acid binding; RNA binding; translation initiation factor activity; nucleotide binding
Biological Process: developmental growth; translation; sexual reproduction; translational initiation
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Product Notes
The Mouse EIF4H eif4h (Catalog #AAA9343184) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9343184 ELISA Kit recognizes Mouse EIF4H. It is sometimes possible for the material contained within the vial of "eukaryotic translation initiation factor 4H, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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