EIF4E-Binding Protein 2/EIF4EBP2 Recombinant Protein | EIF4EBP2 recombinant protein

Recombinant Human EIF4E-Binding Protein 2/EIF4EBP2 Protein (N-6His)

Cat. Num. AAA2552613

• Gene Names: EIF4EBP2; 4EBP2; PHASII
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: EIF4E-Binding Protein 2/EIF4EBP2; Recombinant Human EIF4E-Binding Protein 2/EIF4EBP2 Protein (N-6His); Eukaryotic Translation Initiation Factor 4E-Binding Protein 2; 4E-BP2; eIF4E-Binding Protein 2; EIF4EBP2; EIF4EBP2 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM Tris HCl, 150mM NaCl, pH 8.0.
• Sequence Positions: Met1-Ile120
• Sequence Length: 120

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for EIF4EBP2 recombinant protein

Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 (EIF4EBP2) is a member of the Eukaryotic Translation Initiation Factor 4E Binding Protein Family. EIF4EBP2 regulates eIF4E activity by preventing its assembly into the eIF4F complex, mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway. This regulation of is associated to cell proliferation, cell differentiation and viral infection. Phosphorylated EIF4EBP2 on serine and threonine residues in response to insulin, EGF and PDGF.

NCBI and Uniprot Product Information

• NCBI GI #: 4758260
• NCBI GeneID: 1979
• NCBI Accession #: NP_004087.1
• NCBI GenBank Nucleotide #: NM_004096.4
• UniProt Accession #: Q13542
• Molecular Weight: Molecular Mass: 15.1 kDa; Actual Protein Molecular Mass: 17 kDa
• NCBI Official Full Name: eukaryotic translation initiation factor 4E-binding protein 2
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 4E binding protein 2
• NCBI Official Symbol: EIF4EBP2
• NCBI Official Synonym Symbols: 4EBP2; PHASII
• NCBI Protein Information: eukaryotic translation initiation factor 4E-binding protein 2
• UniProt Protein Name: Eukaryotic translation initiation factor 4E-binding protein 2
• Protein Family: Eukaryotic translation initiation factor 4E-binding protein
• UniProt Gene Name: EIF4EBP2
• UniProt Synonym Gene Names: 4E-BP21 PublicationManual assertion based on opinion iniRef.1; eIF4E-binding protein 21 PublicationManual assertion based on opinion iniRef.1

NCBI Description

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]

Uniprot Description

Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways ().