EGF Like Domain Multiple 6 Recombinant Protein | EGFL6 recombinant protein

Recombinant Human EGF Like Domain Multiple 6

Cat. Num. AAA146746

• Gene Names: EGFL6; W80; MAEG
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: EGF Like Domain Multiple 6; Recombinant Human EGF Like Domain Multiple 6; EGFL6 Human; MAM and EGF Domains-Containing Gene Protein; MAM and EGF Domain Containing; EGF-Like Protein 6; MAEG; EGF Repeat-Containing Protein 6; W80; EGFL6; EGF Like Domain Multiple 6 Human Recombinant; EGFL6 recombinant protein

• Host: HEK (Human embryonic kidney cells)
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: Sterile filtered white lyophilized (freeze-dried) powder.; The EGFL6 protein was lyophilized from a 0.2 um filtered solution in 20mM MES and 500mM NaCl, pH 6.0.
• Sequence Length: 554

• Solubility: It is recommended to reconstitute the lyophilized EGFL6 in sterile PBS at 500 ug/ml, which can then be further diluted to other aqueous solutions.

Related Product Information for EGFL6 recombinant protein

Description: EGF Like Domain Multiple 6 Human Recombinant produced in HEK cells is a polypeptide chain (Asn22-Arg363) containing a total of 348 amino acids (including a 6xHis tag at C-terminus) and having a predicted molecular mass of 40kDa. The EGFL6 is purified by proprietary chromatographic techniques.
Introduction: Epidermal Growth Factor­like Domain Multiple 6 (EGFL6) belongs to the EGF repeat superfamily of proteins, whose members are involved in the regulation of cell cycle, proliferation, and developmental processes. EGFL6 gene product contains a signal peptide, suggesting that EGFL6 is secreted; an EGF repeat region consisting of four complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is assumed to have an adhesive function. Within shared regions, human EGFL6 shares 75% and 78% amino acid sequence identity with the mouse and rat orthologs, respectively. EGFL6 is expressed in various fetal tissues during early development such as the lung, heart, liver, spleen, cochlea and the placenta, as well as meningioma tumors.

Product Categories/Family for EGFL6 recombinant protein

Cytokines and Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 268607667
• NCBI GeneID: 25975
• NCBI Accession #: NP_001161362.1
• NCBI GenBank Nucleotide #: NM_001167890.1
• UniProt Accession #: Q8IUX8; Q6UXJ1; Q8NBV0; Q8WYG3; Q9NY67; Q9NZL7; Q9UFK6; B2RCB1
• Molecular Weight: 61,388 Da
• NCBI Official Full Name: epidermal growth factor-like protein 6 isoform 2
• NCBI Official Synonym Full Names: EGF like domain multiple 6
• NCBI Official Symbol: EGFL6
• NCBI Official Synonym Symbols: W80; MAEG
• NCBI Protein Information: epidermal growth factor-like protein 6
• UniProt Protein Name: Epidermal growth factor-like protein 6
• Protein Family: Epidermal growth factor-like protein
• UniProt Gene Name: EGFL6
• UniProt Synonym Gene Names: MAEG; EGF-like protein 6

NCBI Description

This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]

Uniprot Description

EGFL6: May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly. Belongs to the nephronectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: extracellular space

Molecular Function: integrin binding

Biological Process: cell cycle