Elongation factor 1-delta Recombinant Protein | EF1D recombinant protein

Recombinant Human Elongation factor 1-delta

Cat. Num. AAA1048389

• Gene Names: EEF1D; EF1D; EF-1D; FP1047
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Elongation factor 1-delta; Recombinant Human Elongation factor 1-delta; Antigen NY-CO-4; EF1D recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-281aa; Full Length
• Sequence: ATNFLAHEKIWFDKFKYDDAERRFYEQMNGPVAGASRQENGASVILRDIARARENIQKSLAGSSGPGASSGTSGDHGELVVRIASLEVENQSLRGVVQELQQAISKLEARLNVLEKSSPGHRATAPQTQHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLEACVRSIQLDGLVWGASKLVPVGYGIRKLQIQCVVEDDKVGTDLLEEEITKFEEHVQSVDIAAFNKI
• Sequence Length: 647

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for EF1D recombinant protein

Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).

Product Categories/Family for EF1D recombinant protein

Epigenetics and Nuclear Signaling

References

The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta.Sanders J.P., Raggiaschi R., Morales J., Moeller W.Biochim. Biophys. Acta 1174:87-90(1993)

NCBI and Uniprot Product Information

• NCBI GI #: 304555583
• NCBI GeneID: 1936
• NCBI Accession #: NP_001123525.2
• NCBI GenBank Nucleotide #: NM_001130053.2
• UniProt Accession #: P29692; Q4VBZ6; Q969J1; Q96I38; B4DDU4; D3DWK3; E9PBQ9
• Molecular Weight: 35 kDa
• NCBI Official Full Name: elongation factor 1-delta isoform 1
• NCBI Official Synonym Full Names: eukaryotic translation elongation factor 1 delta
• NCBI Official Symbol: EEF1D
• NCBI Official Synonym Symbols: EF1D; EF-1D; FP1047
• NCBI Protein Information: elongation factor 1-delta
• UniProt Protein Name: Elongation factor 1-delta
• Protein Family: Elongation factor
• UniProt Gene Name: EEF1D
• UniProt Synonym Gene Names: EF1D; EF-1-delta
• UniProt Entry Name: EF1D_HUMAN

NCBI Description

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]

Uniprot Description

EEF1D: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Belongs to the EF-1-beta/EF-1-delta family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation elongation; Translation

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; eukaryotic translation elongation factor 1 complex; nucleolus; nucleus

Molecular Function: DNA binding; heat shock protein binding; protein binding; signal transducer activity; transcription activator binding; translation elongation factor activity; translation factor activity, nucleic acid binding

Biological Process: cellular protein metabolic process; gene expression; mRNA transcription; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent; translation; translational elongation