Mouse embryonic ectoderm development ELISA Kit | EED elisa kit
Mouse Polycomb protein EED, EED ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
EED: a member of the superfamily of Polycomb group (PcG) methyltransferase proteins with WD-40 repeats. PcG complexes mediate chromatin modifications that contribute to transcriptional silencing during development and carcinogenesis. A part of the Polycomb-repressive complex 2 (PRC2) along with EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. Interacts with HDAC, HDAC2, histone H1 and YY1. PRC2 trimethylates histone H3 on K9 and K27, transcriptionally repressing target gene including HOXC8, HOXA9, MYT1 and CDKN2A. Appears to be overexpressed in breast and colon cancers. Inhibitors of PRC2-mediated gene repression are being investigated as a cancer therapy. EED and EZH2 are also implicated in the silencing of the inactive X chromosome. Three human isoforms produced by alternative splicing or initiation have been described, and additional isoforms may be produced by alternative initiation.
Protein type: Methyltransferase
Cellular Component: nucleoplasm; pronucleus; ESC/E(Z) complex; sex chromatin; cytoplasm; nucleolus; chromosome; nucleus
Molecular Function: identical protein binding; histone methyltransferase activity; protein binding; chromatin binding
Biological Process: histone methylation; genetic imprinting; regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification; negative regulation of transcription from RNA polymerase II promoter
Research Articles on EED
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Product Notes
The Mouse EED eed (Catalog #AAA9327776) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327776 ELISA Kit recognizes Mouse EED. It is sometimes possible for the material contained within the vial of "embryonic ectoderm development, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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