Typical Testing Data/Standard Curve (for reference only)
Human Endothelin-converting enzyme 1 ELISA Kit | ECE1 elisa kit
Human Endothelin-converting enzyme 1 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]
Uniprot Description
ECE1: Converts big endothelin-1 to endothelin-1. Defects in ECE1 are a cause of Hirschsprung disease cardiac defects and autonomic dysfunction (HSCRCDAD). It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction. Belongs to the peptidase M13 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; EC 3.4.24.71; Membrane protein, integral; Vesicle; Protease
Chromosomal Location of Human Ortholog: 1p36.1
Cellular Component: early endosome; endosome; external side of plasma membrane; integral to membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane; vesicle
Molecular Function: endopeptidase activity; metal ion binding; metalloendopeptidase activity; peptide hormone binding; protein binding; protein homodimerization activity
Biological Process: apoptosis; ear development; embryonic digit morphogenesis; heart development; hormone catabolic process; peptide hormone processing; pharyngeal system development; positive regulation of cAMP biosynthetic process; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of receptor recycling; protein processing; regulation of systemic arterial blood pressure by endothelin; regulation of vasoconstriction; regulation of vasodilation; response to cadmium ion; response to drug; response to hypoxia
Disease: Hirschsprung Disease, Cardiac Defects, And Autonomic Dysfunction; Hypertension, Essential
Research Articles on ECE1
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Product Notes
The Human ECE1 ece1 (Catalog #AAA288918) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA288918 ELISA Kit recognizes Human ECE1. It is sometimes possible for the material contained within the vial of "Endothelin-converting enzyme 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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