3-beta-hydroxysteroid-Delta (8),Delta (7)-isomerase (Ebp) Recombinant Protein | Ebp recombinant protein
Recombinant Mouse 3-beta-hydroxysteroid-Delta (8),Delta (7)-isomerase (Ebp)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transmembrane protein that localizes to the endoplasmic reticulum. This protein catalyses the conversion of delta8 to delta7 sterols, an important step in sterol biosynthesis. Mutations in this gene are responsible for the mouse tattered mutant phenotype. Tattered males are embryonic lethal, while heterozygous females have developmental defects. Deficiency of the related gene in human causes X-linked dominant chondrodysplasia punctata. [provided by RefSeq, May 2015]
Uniprot Description
EBP: Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. Defects in EBP are the cause of chondrodysplasia punctata X-linked dominant type 2 (CDPX2); also known as Conradi-Hunermann-Happle syndrome. CDP is a clinically and genetically heterogeneous disorder characterized by punctiform calcification of the bones. The key clinical features of CDPX2 are chondrodysplasia punctata, linear ichthyosis, cataracts and short stature. CDPX2 is a rare disorder of defective cholesterol biosynthesis, biochemically characterized by an increased amount of 8-dehydrocholesterol and cholest-8(9)-en-3-beta-ol in the plasma and tissues. Belongs to the EBP family.
Protein type: EC 5.3.3.5; Membrane protein, integral; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Isomerase; Membrane protein, multi-pass
Cellular Component: endoplasmic reticulum membrane; membrane; intracellular membrane-bound organelle; endoplasmic reticulum; integral to membrane
Molecular Function: isomerase activity; cholestenol delta-isomerase activity; C-8 sterol isomerase activity
Biological Process: steroid metabolic process; cholesterol metabolic process; sterol biosynthetic process; hemopoiesis; lipid metabolic process; cholesterol biosynthetic process; steroid biosynthetic process; sterol metabolic process
Research Articles on Ebp
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Product Notes
The Ebp ebp (Catalog #AAA955342) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-230. The amino acid sequence is listed below: TTNTVPLHPY WPRHLKLDNF VPNDLPTSHI LVGLFSISGG LIVITWLLSS RASVVPLGAG RRLALCWFAV CTFIHLVIEG WFSLYNGILL EDQAFLSQLW KEYSKGDSRY ILSDSFVVCM ETVTACLWGP LSLWVVIAFL RQQPFRFVLQ LVVSMGQIYG DVLYFLTELH EGLQHGEIGH PVYFWFYFVF LNAVWLVIPS ILVLDAIKHL TSAQSVLDSK VMKIKSKHN. It is sometimes possible for the material contained within the vial of "3-beta-hydroxysteroid-Delta (8),Delta (7)-isomerase (Ebp), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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