Probable protein E4 (E4) Recombinant Protein | E4 recombinant protein
Recombinant Probable protein E4 (E4)
NCBI and Uniprot Product Information
Uniprot Description
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes. Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin. Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity. Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism. Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
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Product Notes
The E4 e4 (Catalog #AAA1214785) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-304, Full length protein. The amino acid sequence is listed below: MTKMKQMLIC ILCGHLCITW IQMMCGIRQQ VGSIKLAFTT YMEHLNTIMC YLLMMQRDIV LLENGKLKLI RKLCLLLSLA PHHQGHQEDK QTQTPPPRPP PPPQPPLTPR PDANPSINSH NKPKPNEEGT DGDHQAEQGD RKRTKGDPDP DPGRGPVLKP TLPPPPPPPP TGPGLRRSTR LVLVPGQGPP PDLPAPPVEG EVEGHPQGKD RDHPPPTPQN GHGKETQGAE GGGDKGEQGA VGGESSDGEG DHSQPPLTPP NESDGSLLNT VACLLARWES NFDQLVQNIQ GDLEGYWRKL GTPQ. It is sometimes possible for the material contained within the vial of "Probable protein E4 (E4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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