Viral Macrophage inflammatory Protein-2 Active Protein | vMIP2 active protein
Recombinant Viral Macrophage inflammatory Protein-2
Purity
Greater than 97.0% as determined by RP-HPLC & SDS-PAGE.
Synonyms
Viral Macrophage inflammatory Protein-2; Recombinant Viral Macrophage inflammatory Protein-2; MIP2 Viral; MIP-2 Viral Recombinant; MIP-2 Viral; Viral MIP-2; Viral MIP2; vMIP2 active protein
Host
E Coli
Purity/Purification
Greater than 97.0% as determined by RP-HPLC & SDS-PAGE.
Form/Format
Lyophilized from 1mg/ml solution containing 20mM Phospahte Buffer, pH 7.4 % 0.15M NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
LGASWHRPDK CCLGYQKRPL PQVLLSSWYP TSQLCSKPGV IFLTKRGRQVCADKSKDWVK KLMQQLPVTA
Sequence Length
94
Solubility
It is recommended to reconstitute the lyophilized CXCL2 Viral in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
Determined by the inhibitory effect on monocyte migration response to human MIP1A using a concentration range of 1 ug-10 ug/ml of viral MIP2 which will inhibit 25ng/ml of human MIP1A.
Preparation and Storage
Lyophilized MIP-2 Viral protein although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CXCL2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Related Product Information for vMIP2 active protein
Description: MIP-2 Viral Recombinant produced in E Coli is a single,non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7.9 kDa. The MIP-2 is purified by proprietary chromatographic techniques.
Introduction: Viral MIP-2 is closely related to MIP-1alpha, show amino acid sequence similarity of about 41%. At the amino acid sequence level, Viral MIP-1 and Viral MIP-2 share 48% similarity. Viral MIP-1 and Viral MIP-2 are more closely linked to one another phylogenetically than to other human chemokines, signifying that they have gene duplication within the virus rather than by two independent gene aquisitions. Viral MIP-2 binds to the CCR3 chemokine receptor through which eotaxin and other beta chemokines activate eosinophils. Viral MIP-2 activates and chemoattract human eosinphils.
Introduction: Viral MIP-2 is closely related to MIP-1alpha, show amino acid sequence similarity of about 41%. At the amino acid sequence level, Viral MIP-1 and Viral MIP-2 share 48% similarity. Viral MIP-1 and Viral MIP-2 are more closely linked to one another phylogenetically than to other human chemokines, signifying that they have gene duplication within the virus rather than by two independent gene aquisitions. Viral MIP-2 binds to the CCR3 chemokine receptor through which eotaxin and other beta chemokines activate eosinophils. Viral MIP-2 activates and chemoattract human eosinphils.
Product Categories/Family for vMIP2 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
10,486 Da
NCBI Official Full Name
Viral macrophage inflammatory protein 2
NCBI Official Symbol
K4
NCBI Protein Information
interleukin 8-like CC chemokine; K4; vCCL-2; vMIP-II
UniProt Protein Name
Viral macrophage inflammatory protein 2
UniProt Gene Name
ORF K4
UniProt Synonym Gene Names
vMIP-II
UniProt Entry Name
VMI2_HHV8P
Uniprot Description
Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.
Research Articles on vMIP2
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Product Notes
The vMIP2 orf k4 (Catalog #AAA144127) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: LGASWHRPDK CCLGYQKRPL PQVLLSSWYP TSQLCSKPGV IFLTKRGRQV CADKSKDWVK KLMQQLPVTA. It is sometimes possible for the material contained within the vial of "Viral Macrophage inflammatory Protein-2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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