Neurotrophin-4 Active Protein | NT 4 active protein
Recombinant Human Neurotrophin-4
Sterile Filtered White lyophilized (freeze-dried) powder.
Introduction: NT-4 is part of the family of neurotrophic factors, neurotrophins, that are in charge for the survival and differentiation of mammalian neurons. NT-4 expression is dominant and less influenced by environmental signals. NT-4 deficient mice shows slight cellular deficits and develop normally to adulthood. NT-4 is a target-derived survival factor for peripheral sensory sympathetic neurons.NT-4 is involved in the proliferation and differentiation of periodontal ligament cells.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
Uniprot Description
NT-4/5: Target-derived survival factor for peripheral sensory sympathetic neurons. Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O). A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Belongs to the NGF-beta family.
Protein type: Secreted; Secreted, signal peptide; Cytokine; Cell development/differentiation
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: endoplasmic reticulum lumen; cytoplasmic membrane-bound vesicle; extracellular region
Molecular Function: neurotrophin p75 receptor binding; growth factor activity
Biological Process: epidermis development; mechanoreceptor differentiation; long-term memory; cell-cell signaling; regulation of neuron differentiation; adult locomotory behavior; sensory organ boundary specification; ganglion mother cell fate determination; negative regulation of neuron apoptosis; neurite morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Glaucoma 1, Open Angle, O
Research Articles on NT 4
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Product Notes
The NT 4 ntf4 (Catalog #AAA143528) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA. It is sometimes possible for the material contained within the vial of "Neurotrophin-4, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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