M-CSF active protein
Mouse M-CSF
NCBI and Uniprot Product Information
Uniprot Description
Function: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Subunit structure: Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R. Ref.14
Subcellular location: Cell membrane; Single-pass type I membrane protein
By similarity. Processed macrophage colony-stimulating factor 1: Secreted › extracellular space
By similarity.
Post-translational modification: N-glycosylated. The predominant soluble form is a chondroitin sulfate-containing proteoglycan.
Involvement in disease: A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling. Ref.13
Caution: The sequence reported in Ref.3 was thought to originate from rat, but was later shown (Ref.10 and Ref.11) to be derived from mouse.
Research Articles on M-CSF
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Product Notes
The M-CSF csf1 (Catalog #AAA691968) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse M-CSF reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MKEVSEHCSH MIGNGHLKVL QQLIDSQMET SCQIAFEFVD QEQLDD PVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS C FTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFT KNC NNSFAKCSSR DVVTKP. It is sometimes possible for the material contained within the vial of "M-CSF, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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