LIX/CXCL5 (93 aa) Active Protein | LIX/CXCL5 active protein
Mouse LIX/CXCL5 (93 aa)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]
Uniprot Description
Function: May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation. Ref.6
Subcellular location: Secreted.
Induction: By lipopolysaccharide (LPS).
Post-translational modification: GCP-2(1-78) and GCP-2(9-78) are produced by proteolytic cleavage after secretion from fibroblasts and epithelial cells. GCP-2(9-78) is the most prominent form. A number of additional N-terminal (processed between pos. 41 and 48) and C-terminal (processed between pos. 118 and 132) processed forms have been identified, probably also representing intermediate states.
Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.
Research Articles on LIX/CXCL5
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Product Notes
The LIX/CXCL5 cxcl5 (Catalog #AAA691801) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse LIX/CXCL5 (93 aa) reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: APSSVIAATE LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIA KLKN QKEVCLDPEA PVIKKIIIQK ILGSDKKKAK RNALAVERTA S VQ. It is sometimes possible for the material contained within the vial of "LIX/CXCL5 (93 aa), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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