Leptin Active Protein | Lep active protein
Mouse Leptin
Gene Names
Lep; ob; obese
Reactivity
Mouse
Purity
> 95% (SDS-PAGE; HPLC)
Synonyms
Leptin; Mouse Leptin; Recombinant Murine Leptin; Lep active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 95% (SDS-PAGE; HPLC)
Form/Format
Lyophilized
Sequence
MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGL HPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL L AFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDI LQQ LDVSPEC
Sequence Length
167
Endotoxin Level
< 0.1 ng/ug of Leptin
Biological Activity
Murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 ug Leptin/gm of body weight for 14 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.
Related Product Information for Lep active protein
Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Rat Leptin is a 16.2 kDa protein containing 147 amino acid residues.
Product Categories/Family for Lep active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
16.0 kDa
NCBI Official Full Name
leptin
NCBI Official Synonym Full Names
leptin
NCBI Official Symbol
Lep
NCBI Official Synonym Symbols
ob; obese
NCBI Protein Information
leptin; obesity factor
UniProt Protein Name
Leptin
Protein Family
UniProt Gene Name
Lep
UniProt Synonym Gene Names
Ob
UniProt Entry Name
LEP_MOUSE
Uniprot Description
Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Subcellular location: Secreted
Probable.
Involvement in disease: Defects in Lep are the cause of profound obesity and type II diabetes.
Sequence similarities: Belongs to the leptin family.
Research Articles on Lep
Similar Products
Product Notes
The Lep lep (Catalog #AAA691546) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse Leptin reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGL HPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL L AFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDI LQQ LDVSPEC. It is sometimes possible for the material contained within the vial of "Leptin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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