IL-1 alpha active protein
Mouse IL-1 alpha
Gene Names
Il1a; Il-1a
Reactivity
Mouse
Purity
> 98% (SDS-PAGE; HPLC)
Synonyms
IL-1 alpha; Mouse IL-1 alpha; Recombinant Murine IL-1alpha; IL-1 alpha active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% (SDS-PAGE; HPLC)
Form/Format
Lyophilized
Sequence
SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWL NDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP V LLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKE QSR VHLARGLPSM TDFQIS
Sequence Length
270
Endotoxin Level
< 0.1 ng/ug of IL-1alpha
Biological Activity
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is < 0.002 ng/ml, corresponding to a specific activity of > 5 x 108 units/mg.
Related Product Information for IL-1 alpha active protein
IL-1alpha is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine. Recombinant murine IL-1alpha is an 17.9 kDa protein containing 156 amino acid residues.
Product Categories/Family for IL-1 alpha active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
17.9 kDa
NCBI Official Full Name
interleukin-1 alpha
NCBI Official Synonym Full Names
interleukin 1 alpha
NCBI Official Symbol
Il1a
NCBI Official Synonym Symbols
Il-1a
NCBI Protein Information
interleukin-1 alpha; IL-1 alpha
UniProt Protein Name
Interleukin-1 alpha
UniProt Gene Name
Il1a
UniProt Synonym Gene Names
IL-1 alpha
UniProt Entry Name
IL1A_MOUSE
Uniprot Description
Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Subunit structure: Monomer.
Subcellular location: Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
Sequence similarities: Belongs to the IL-1 family.
Research Articles on IL-1 alpha
Similar Products
Product Notes
The IL-1 alpha il1a (Catalog #AAA691985) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse IL-1 alpha reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWL NDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP V LLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKE QSR VHLARGLPSM TDFQIS. It is sometimes possible for the material contained within the vial of "IL-1 alpha, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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