CD40 Ligand/TRAP, soluble Active Protein | CD40 Ligand/TRAP active protein
Mouse CD40 Ligand/TRAP, soluble
Gene Names
Cd40lg; IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5
Reactivity
Mouse
Purity
> 98% by SDS-PAGE
Synonyms
CD40 Ligand/TRAP; soluble; Mouse CD40 Ligand/TRAP; Recombinant Murine sCD40 Ligand; CD40 Ligand/TRAP active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% by SDS-PAGE
Form/Format
Lyophilized
Sequence
MQRGDEDPQI AAHVVSEANS NAASVLQWAK KGYYTMKSNL VMLENG KQLT VKREGLYYVY TQVTFCSNRE PSSQRPFIVG LWLKPSSGSE R ILLKAANTH SSSQLCEQQS VHLGGVFELQ AGASVFVNVT EASQVIH RVG FSSFGLLKL
Sequence Length
260
Endotoxin Level
< 0.1 ng per ug of sCD40
Biological Activity
Determined by its ability to induce TNF-alpha and MIP-1alpha production by murine splenocytes. The expected ED50 for this effect is < 0.1 ug/ml.
Related Product Information for CD40 Ligand/TRAP active protein
CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant murine CD40L is a soluble 16.4 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.
Product Categories/Family for CD40 Ligand/TRAP active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
16.4 kDa
NCBI Official Full Name
CD40 ligand
NCBI Official Synonym Full Names
CD40 ligand
NCBI Official Symbol
Cd40lg
NCBI Official Synonym Symbols
IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5
NCBI Protein Information
CD40 ligand; T-cell antigen Gp39; TNF-related activation protein; tumor necrosis factor ligand superfamily member 5
UniProt Protein Name
CD40 ligand
UniProt Gene Name
Cd40lg
UniProt Synonym Gene Names
Cd40l; Tnfsf5; CD40-L; TRAP
UniProt Entry Name
CD40L_MOUSE
Uniprot Description
Function: Cytokine that binds to TNFRSF5. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching
By similarity.
Subunit structure: Homotrimer.
Subcellular location: Cell membrane; Single-pass type II membrane protein. CD40 ligand, soluble form: Secreted.
Tissue specificity: Specifically expressed on activated CD4+ T-lymphocytes.
Post-translational modification: The soluble form derives from the membrane form by proteolytic processing
By similarity.
Sequence similarities: Belongs to the tumor necrosis factor family.
Research Articles on CD40 Ligand/TRAP
Similar Products
Product Notes
The CD40 Ligand/TRAP cd40lg (Catalog #AAA691869) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse CD40 Ligand/TRAP, soluble reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MQRGDEDPQI AAHVVSEANS NAASVLQWAK KGYYTMKSNL VMLENG KQLT VKREGLYYVY TQVTFCSNRE PSSQRPFIVG LWLKPSSGSE R ILLKAANTH SSSQLCEQQS VHLGGVFELQ AGASVFVNVT EASQVIH RVG FSSFGLLKL. It is sometimes possible for the material contained within the vial of "CD40 Ligand/TRAP, soluble, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
