Keratinocyte Growth Factor-2 Active Protein | mKGF 2 active protein
Recombinant Mouse Keratinocyte Growth Factor-2
Sterile Filtered White lyophilized (freeze-dried) powder.
Introduction: KGF-2 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing.
NCBI and Uniprot Product Information
Uniprot Description
FGF10: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Belongs to the heparin-binding growth factors family.
Protein type: Secreted; Cytokine; Secreted, signal peptide; Cell development/differentiation; Motility/polarity/chemotaxis
Cellular Component: extracellular matrix; extracellular space; cell surface; cell; extracellular region; plasma membrane; nucleus
Molecular Function: heparin binding; protein binding; growth factor activity; type 2 fibroblast growth factor receptor binding; fibroblast growth factor receptor binding; chemoattractant activity; receptor binding
Biological Process: salivary gland development; activation of MAPK activity; urothelial cell proliferation; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; muscle cell fate commitment; regulation of saliva secretion; embryonic pattern specification; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; positive regulation of fibroblast proliferation; epithelial cell proliferation; cell-cell signaling; positive chemotaxis; embryonic digestive tract morphogenesis; induction of an organ; embryonic gut development; embryonic genitalia morphogenesis; spleen development; positive regulation of keratinocyte migration; inner ear morphogenesis; positive regulation of DNA repair; fibroblast growth factor receptor signaling pathway; semicircular canal morphogenesis; positive regulation of urothelial cell proliferation; organ growth; positive regulation of peptidyl-tyrosine phosphorylation; organ morphogenesis; branching morphogenesis of a tube; regulation of gene expression; blood vessel morphogenesis; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; alveolus development; positive regulation of epithelial cell proliferation; limb development; epidermis development; wound healing; radial glial cell differentiation; positive regulation of mitotic cell cycle; chemotaxis; regulation of epithelial cell proliferation; positive regulation of vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis; negative regulation of cell proliferation; establishment of mitotic spindle orientation; epithelial cell differentiation; positive regulation of MAPKKK cascade; positive regulation of lymphocyte proliferation; epidermis morphogenesis; salivary gland morphogenesis; pancreas development; positive regulation of cell proliferation; male genitalia morphogenesis; thyroid gland development; lacrimal gland development; otic vesicle formation; positive regulation of Wnt receptor signaling pathway; female genitalia morphogenesis; positive regulation of Notch signaling pathway; organ formation; hair follicle morphogenesis; thymus development; keratinocyte proliferation; regulation of activin receptor signaling pathway; limb morphogenesis; embryonic camera-type eye development; odontogenesis of dentine-containing teeth; limb bud formation; negative regulation of cell differentiation; gut development; pituitary gland development; positive regulation of ATPase activity; actin cytoskeleton reorganization; white fat cell differentiation; blood vessel remodeling; positive regulation of Ras protein signal transduction; positive regulation of DNA replication; regulation of smoothened signaling pathway; lung development
Research Articles on mKGF 2
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Product Notes
The mKGF 2 fgf10 (Catalog #AAA144840) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: QALGQDMVSQ EATNCSSSSS SFSSPSSAGR HVRSYNHLQG DVRWRRLFSF TKYFLTIEKN GKVSGTKNED CPYSVLEITS VEIGVVAVKA INSNYYLAMN KKGKLYGSKE FNNDCKLKER IEENGYNTYA SFNWQHNGRQ MYVALNGKGA PRRGQKTRRK NTSAHFLPMT IQT. It is sometimes possible for the material contained within the vial of "Keratinocyte Growth Factor-2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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