Neuroserpin Active Protein | SERPINI1 active protein

Human Neuroserpin

Cat. Num. AAA695768

• Gene Names: SERPINI1; PI12; neuroserpin
• Reactivity: Species Reactivity: Human; Cross Reactivity: Rat
• Purity: Above 96% as determined by SDS-PAGE Analysis.
• Synonyms: Neuroserpin; Human Neuroserpin; Recombinant Human Neuroserpin; SERPINI1 active protein

• Host: E Coli
• Reactivity: Species Reactivity: Human; Cross Reactivity: Rat
• Purity/Purification: Above 96% as determined by SDS-PAGE Analysis.
• Sequence: MTGATFPEE AIADLSVNM YNRLRATGE DENILFSPL SIALAMGMM ELGAQGSTQ KEIRHSMGY DSLKNGEEF SFLKEFSNM VTAKESQYV MKIANSLFV QNGFHVNEE FLQMMKKYF NAAVNHVDF SQNVAVANY INKWVENNT NNLVKDLVS PRDFDAATY LALINAVYF KGNWKSQFR PENTRTFSF TKDDESEVQ IPMMYQQGE FYYGEFSDG SNEAGGIYQ VLEIPYEGD EISMMLVLS RQEVPLATL EPLVKAQLV EEWANSVKK QKVEVYLPR FTVEQEIDL KDVLKALGI TEIFIKDAN LTGLSDNKE IFLSKAIHK SFLEVNEEG SEAAAVSGM IAISRMAVL YPQVIVDHP FFFLIRNRR TGTILFMGR VMHPETMNT SGHDFEEL

• Biological Activity: Determined by the dose-dependent stimulation of the proliferation of rat C6 cells using a concentration range of 0.3-0.6 mug/ml.
• Cell Type: Neurons
• Preparation and Storage: At -20 degree C

Testing Data

Related Product Information for SERPINI1 active protein

Neuroserpin is an inhibitory serpin that is expressed predominantly in central nervous system. Although the physiological target of neuroserpin is still unclear, cumulative evidence suggest that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. In the adult brain, neuroserpin is secreted from the growth cones of neurons in areas where synaptic changes are associated with learning and memory, i.e. cerebral cortex, hippocampus, and amygdala. The neuroprotective role of neuroserpin has been demonstrated in transgenic mice lacking neuroserpin expression. The deficiency of neuroserpin in these mice was associated with motor neuron disease characterized by axonal degradation. In humans, defects in neuroserpin, caused by point mutations in the neuroserpin gene, underlie a hereditary disorder called the familial encephalopathy with neuroserpin inclusion bodies (FENIB). Recombinant human neuroserpin is a 44.8 kDa non-glycosylated protein containing 395 amino-acid residues.

Product Categories/Family for SERPINI1 active protein

Neurosciences

NCBI and Uniprot Product Information

• NCBI GI #: 3183087
• NCBI GeneID: 5274
• UniProt Accession #: Q99574; Q6AHZ4; A8K217; D3DNP1
• Molecular Weight: 46,427 Da
• NCBI Official Full Name: Neuroserpin
• NCBI Official Synonym Full Names: serpin peptidase inhibitor, clade I (neuroserpin), member 1
• NCBI Official Symbol: SERPINI1
• NCBI Official Synonym Symbols: PI12; neuroserpin
• NCBI Protein Information: neuroserpin; PI-12; serpin I1; peptidase inhibitor 12; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
• UniProt Protein Name: Neuroserpin
• Protein Family: Neuroserpin
• UniProt Gene Name: SERPINI1
• UniProt Synonym Gene Names: PI12; PI-12
• UniProt Entry Name: NEUS_HUMAN

NCBI Description

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: regulation of cell adhesion; central nervous system development; peripheral nervous system development

Disease: Encephalopathy, Familial, With Neuroserpin Inclusion Bodies