Testing Data
MCP-2 active protein
Murine MCP-2 (CCL8)
Reactivity
Species Reactivity: MouseCross Reactivity: Human
Purity
Above 98% as determined by SDS-PAGE Analysis.
Synonyms
MCP-2; Murine MCP-2 (CCL8); Recombinant Murine MCP-2 (CCL8); MCP-2 active protein
Host
E Coli
Reactivity
Species Reactivity: Mouse
Cross Reactivity: Human
Cross Reactivity: Human
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Sequence
GPDKAPVTC CFHVLKLKI PLRVLKSYE RINNIQCPM EAVVFQTKQ GMSLCVDPT QKWVSEYME ILDQKSQIL QP
Biological Activity
Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-100.0 ng/ml.
Cell Type
Monocytes and Macrophages, NK and NKT Cells, T Cells, Dendritic Cells
Preparation and Storage
At -20 degree C
Testing Data
Testing Data
Related Product Information for MCP-2 active protein
The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. Recombinant murine MCP-2 is an 8.5 kDa protein containing 74 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Product Categories/Family for MCP-2 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
11,017 Da
NCBI Official Full Name
C-C motif chemokine 8
NCBI Official Symbol
LOC102641794
NCBI Protein Information
c-C motif chemokine 8-like
UniProt Protein Name
C-C motif chemokine 8
UniProt Gene Name
Ccl8
UniProt Synonym Gene Names
Mcp2; Scya8; MCP-2
UniProt Entry Name
CCL8_MOUSE
Uniprot Description
CCL8: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Cellular Component: extracellular space; extracellular region
Molecular Function: heparin binding; chemokine activity; cytokine activity
Biological Process: immune response; inflammatory response; chemotaxis; positive regulation of myoblast differentiation
Similar Products
Product Notes
The MCP-2 ccl8 (Catalog #AAA696155) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Murine MCP-2 (CCL8) reacts with Species Reactivity: Mouse Cross Reactivity: Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GPDKAPVTC CFHVLKLKI PLRVLKSYE RINNIQCPM EAVVFQTKQ GMSLCVDPT QKWVSEYME ILDQKSQIL QP. It is sometimes possible for the material contained within the vial of "MCP-2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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