TWEAK active protein
Human TWEAK
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
Uniprot Description
Function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. Ref.7 Ref.10
Subunit structure: Homotrimer
Probable. Interacts with the angiogenic factor AGGF1/VG5Q. Ref.8 Ref.10
Subcellular location: Cell membrane; Single-pass type II membrane protein Ref.3. Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted Ref.3. Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein Ref.3.
Tissue specificity: Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Post-translational modification: The soluble form derives from the membrane form by proteolytic processing.
Sequence similarities: Belongs to the tumor necrosis factor family.
Sequence caution: The sequence AAH19047.1 differs from that shown. Reason: Frameshift at position 125.
Research Articles on TWEAK
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Product Notes
The TWEAK tnfsf12 (Catalog #AAA692021) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human TWEAK reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSS SPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG V LALRCLEEF SATAASSLGP QLRLCQVSGL LALRPGSSLR IRTLPWA HLK AAPFLTYFGL FQVH. It is sometimes possible for the material contained within the vial of "TWEAK, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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