SCGF-beta active protein
Human SCGF-beta
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation. Ref.7
Subcellular location: Cytoplasm. Secreted Ref.8.
Tissue specificity: Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver. Ref.1 Ref.2 Ref.7 Ref.8
Developmental stage: In the bone marrow, expression is limited to immature neutrophils. Expression was not detected in circulating mature neutrophils. Ref.8
Post-translational modification: O-glycosylated. Probably sulfated on the O-glycans. Ref.1
Sequence similarities: Contains 1 C-type lectin domain.
Research Articles on SCGF-beta
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Product Notes
The SCGF-beta clec11a (Catalog #AAA692052) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human SCGF-beta reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MGHGARGAER EWEGGWGGAQ EEEREREALM LKHLQEALGL PAGRGD ENPA GTVEGKEDWE MEEDQGEEEE EEATPTPSSG PSPSPTPEDI V TYILGRLAG LDAGLHQLHV RLHALDTRVV ELTQGLRQLR NAAGDTR DAV QALQEAQGRA EREHGRLEGC LKGLRLGHKC FLLSRDFEAQ PS ASPHPLSP DQPNGGTLEN CVAQASDDGS WWDHDCQRRL YYVCEFPF. It is sometimes possible for the material contained within the vial of "SCGF-beta, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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